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Metformin - Overview

Metformin, marketed under the name Glucophage, is used in the treatment of type 2 diabetes as well as polycystic ovary syndrome (PCOS). Push Health can connect people in need of a metformin prescription with a licensed medical provider who can prescribe the medication when appropriate to do so.

What Is Metformin Used For?

Metformin is an oral antihyperglycemic medication that helps improve glucose tolerance and lowers postprandial and basal glucose levels in the plasma, likely through decreasing the absorption and production of glucose by the liver and improving insulin sensitivity. Metformin is used in a variety of clinical conditions:

Type 2 Diabetes

Metformin is a first-line medication for type 2 diabetes for many adults and some children (age 10 and older). It is used alongside lifestyle modifications - diet and exercise - to improve glycemic control.

Polycystic Ovary Syndrome (PCOS)

Metformin is sometimes prescribed off-label for polycystic ovary syndrome (PCOS). In PCOS, metformin may improve insulin resistance, menstrual regularity, androgen-related symptoms, and fertility outcomes. The medication is sometimes used in PCOS patients without a formal type 2 diabetes diagnosis.

Prediabetes Prevention

Metformin is sometimes used off-label to slow the progression from prediabetes to type 2 diabetes in higher-risk adults in conjunction with lifestyle measures.

Other Uses

There is some interest in understanding if and how metformin medication use might influence the aging process. The TAME (Targeting Aging with Metformin) trial has been studying metformin across multiple aging biomarkers and age-related conditions.

Metformin - Dosage and Cost

Metformin is typically available as 500 mg, 850 mg and 1000 mg tablets and is generally available in both generic and branded forms. Because metformin is cleared by the kidneys, dosing depends on kidney function. Metformin is combined with glyburide in the medication Glucovance and linagliptin (Tradjenta) in the medication Jentadueto. Metformin is also combined with the dapagliflozin to form Xigduo, with canagliflozin to form Invokamet, and with Januvia in Janumet. Metformin is sometimes also prescribed with glipizide (Glucotrol) and glimepiride (Amaryl).

Metformin tablets are considered affordable, with generic versions costing under ten cents per pill at many pharmacies. Insurance may help with medication costs and prescription savings cards may also be available. Metformin tablets should be typically be stored at 20° to 25° C but confirm with the package insert.

Can I Buy Metformin Online?

Metformin requires a prescription from a medical provider to be dispensed in the US. Push Health can connect people who might need a metformin prescription with medical providers who can prescribe the medication to a local or delivery pharmacy when appropriate to do so.

Frequently Asked Questions about Metformin

What is metformin used for?

Metformin is a first-line medication for type 2 diabetes and is commonly used for polycystic ovary syndrome (PCOS) and prediabetes prevention (selected cases).

Should I take metformin with food?

Yes. Taking metformin with food significantly reduces gastrointestinal side effects like nausea and diarrhea, especially when starting the medication.

What is metformin ER?

Metformin ER (extended-release) is a once or twice daily formulation that releases the medication slowly over several hours as opposed to immediately. The primary benefit of the ER formulation is fewer gastrointestinal side effects.

Does metformin cause weight loss?

Metformin is associated with modest weight reduction in patients who are overweight or have significant insulin resistance. It is not FDA-approved as a weight loss medication.

Can metformin be used for PCOS without diabetes?

Yes. The medication is sometimes prescribed off-label for PCOS if there may be a benefit to insulin resistance or androgen issues.

Can metformin be used for prediabetes?

Yes. Metformin is used off-label to reduce the risk of progression from prediabetes to type 2 diabetes. The American Diabetes Association recommends considering metformin for prediabetes prevention in certain patients. A provider can evaluate whether metformin is appropriate for prediabetes management.

Does metformin cause lower B12 levels?

Long-term metformin use can reduce vitamin B12 absorption in the intestines. Periodic B12 level checks are recommended.

Can I drink alcohol while taking metformin?

Alcohol should generally be avoided as it can increase the risk of lactic acidosis and destabilize glucose levels.

How much does metformin cost?

Generic metformin is one of the most affordable medications available, generally costing under 10 cents per tablet at most pharmacies.

Metformin - Side Effects

Metformin can cause side effects such as nausea, diarrhea, stomach pain, gas, and a metallic taste when used. These symptoms sometimes improve after dose adjustments. Lactic acidosis is a rare but serious side effect with a higher risk in people with kidney impairment, liver disease, heart failure, dehydration and sepsis. People with kidney problems should discuss this with their medical provider before using the medication.

Metformin medication is sometimes held in people who are receiving iodinated contrast or when suffering from a major illness. People with a hypersensitivity to metformin should not use it. People with unusual muscle pain, severe weakness, trouble breathing, or unexplained drowsiness should seek in-person care. Patients should any other concerns about the medication with their medical provider.

How to Get Metformin with Push Health

  1. Complete a brief health intake. Answer some questions about your health history. Include information about prior diabetes, PCOS, and alcohol use.
  2. Connect with a licensed medical provider. A provider will review your information, connect with you, and evaluate whether metformin is appropriate for you.
  3. Get your prescription electronically. If metformin is appropriate, your provider will send a prescription to a pharmacy of your choice. No office visit required.
  4. Get your medication. Pick up metformin at a retail pharmacy or have it delivered to you.

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More Metformin Information

Last updated September 14, 2026. Given the evolving nature of medicine and science, this information might not be accurate and should not be construed as medical advice or diagnosis / treatment recommendations. Please consult a licensed medical provider if you have additional questions. Please call 911 immediately or go to the nearest emergency room if you believe you are experiencing a medical emergency.