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GLP-1 Medications - Overview
GLP-1 prescription medications (GLP-1 agonists) are medications sometimes prescribed to people who need help with weight loss or to people with diabetes. People who might need a GLP-1 prescription can use Push Health to connect with a medical provider who can prescribe a medication to a patient's pharmacy when appropriate to do so.
What Are GLP-1 Medications Used For?
GLP-1 medications are FDA-approved to improve blood sugar control in type 2 diabetes and, for certain agents, for chronic weight management in adults with obesity or overweight plus a weight-related condition. They are used together with diet and exercise. Examples of drugs that have GLP-1 drugs as a component include the following:
- Dulaglutide (Trulicity)
- Orforglipron (Foundayo)
- Liraglutide (Saxenda, Victoza)
- Semaglutide (Ozempic, Rybelsus, Wegovy)
- Tirzepatide (Mounjaro, Zepbound)
GLP-1 medications are peptide hormones containing 30 amino acids that are produced in the epithelial endocrine L-cells of the intestine and GLP-1 hormone has been found to be released in response to meals. The "GLP-1" in GLP-1 medications stands for glucagon-like peptide-1. GLP-1 medications are thought to work by modulating insulin secretion, gastric emptying and food intake. GLP-1 receptors are thought to be found throughout the body in areas such as the pancreatic beta cells and ducts, gastric mucosa, lungs, heart, kidneys, immune cells, and hypothalamus. Throughout the body, GLP-1 medication agonists may help lower serum glucose levels and regulate metabolism in certain patients.
GLP-1 medications have also shown promise in helping people with a variety of conditions, including obstructive sleep apnea (OSA) and kidney disease related to diabetes. Decreased alcohol consumption has also been observed in rats and is being studied in greater detail.
GLP-1 Medications - Cost and Dosage
Some people may find GLP-1 online medications to be moderately expensive - ranging from hundreds to thousands of dollars - when paying out of pocket. Some manufacturers may offer GLP-1 medication coupons and GLP-1 drug prescription savings cards may also help reduce out-of-pocket costs for GLP-1 prescription medications when buying GLP-1 drugs at a pharmacy. Patients may also find insurance will cover some or all costs associated with the medications although reimbursement patterns are constantly changing.
The GLP-1 medication dosage and regimen used depends on the specific medication being used, the judgment of the prescribing medical provider, and the health needs of the patient. As might be expected, different GLP-1 drugs will require different regimens.
GLP-1 Drugs and Weight Loss
GLP-1 medications are sometimes prescribed for medical weight loss. GLP-1 medications may help stimulate insulin secretion, inhibit glucagon secretion, reduce food intake, and increase satiety - all of which can contribute to reducing weight. Appetite suppression has also been reported in studies. These effects may also be enhanced due to the widespread distribution of GLP-1 receptors in the areas of the nervous system. The secondary benefits of the effects of GLP-1 drugs may also be improvements in lipotoxicity due to reductions in fat distribution. Data examining obesity in the US observed that, for the first time in more than a decade, obesity decreased in 2023 with a notable decrease in the South - a region that had the highest observed per capita GLP-1 dispensing rate.
Can I Buy GLP-1 Medication Online?
GLP-1 medications require a prescription to be dispensed by a pharmacy in the United States. For this reason, GLP-1 medications OTC (over the counter) are not available and one cannot just buy GLP-1 online. The first step to getting a GLP-1 medication prescription is consulting a licensed medical provider. People who might need a GLP-1 drug prescription can use Push Health to connect with a medical provider who can prescribe the medication when appropriate to do so.
Frequently Asked Questions about GLP-1 Medications
What is a GLP-1 medication?
GLP-1 (glucagon-like peptide-1) medications are a class of prescription drugs that mimic or stimulate the a hormone naturally produced in the body and can help increase insulin secretion, slow gastric emptying, and reduce food intake and appetite for the purpose of weight loss and blood sugar control in some people.
What is the difference between Ozempic, Wegovy, Mounjaro, Zepbound, and Foundayo?
Ozempic and Wegovy both contain semaglutide - a GLP-1 receptor agonist. Ozempic is FDA-approved for type 2 diabetes while Wegovy is FDA-approved for weight management. Mounjaro and Zepbound both contain tirzepatide - a dual GLP-1/GIP agonist. Mounjaro is approved for diabetes while Zepbound for weight management. Foundayo (orforglipron) is a small-molecule oral GLP-1 agonist approved for weight management — the only one that can be taken at any time of day without food restrictions.
Is there an oral GLP-1 medication?
Yes. There are now multiple oral options, including Foundayo (orforglipron), Rybelsus (semaglutide), and Wegovy (semaglutide).
What are the most common side effects of GLP-1 medications?
The most common side effects are gastrointestinal symptoms such as nausea, diarrhea, vomiting, and constipation. These symptoms are most pronounced when starting the medication or during dose increases and usually diminish over time. Other side effects include injection site reactions (for injectable forms), headache, and fatigue. Rare but serious side effects include pancreatitis, gallbladder disease, and kidney injury.
Do GLP-1 medications cause muscle loss?
Some muscle loss has been reported alongside fat loss in clinical trials. To minimize this, providers typically recommend adequate protein intake and resistance exercise during treatment.
GLP-1 Medications - Side Effects
GLP-1 prescription medication can cause side effects when used, including nausea, vomiting, and injection site reactions (for injectable versions) such as pain and swelling. The majority of reported side effects tend to be gastrointestinal in nature although skeletal muscle loss has also been reported. GLP-1 medications should typically not be prescribed when there is a history of certain types of familial endocrine disorders or thyroid cancer. GLP-1 drugs and alcohol should not be used together. Possible risks associated with the use of GLP-1 medications during surgery are also being studied. People with a hypersensitivity or allergy to GLP-1 agonist medications, ingredients in the formulation, or similar medications should not use GLP-1 prescription medication. Before using GLP-1 medications, it is important to discuss potential side effects and other concerns with a qualified medical provider.
How to Get a GLP-1 Prescription with Push Health
- Complete a brief health intake. Answer questions about your weight history, BMI, current medications, relevant medical conditions - including diabetes, cancer and pancreatitis.
- Connect with a licensed medical provider. A medicalprovider will review your information and evaluate which medication is most appropriate for your situation. Same-day consultations are available.
- Receive your prescription. When appropriate, your provider will send a prescription to a pharmacy or manufacturer direct-to-patient program of your choice. No office visit is required.
- Begin treatment. GLP-1 medications range in price. Manufacturer savings programs and insurance may significantly reduce out-of-pocket costs.
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Last updated September 9, 2026. Given the evolving nature of medicine and science, this information might not be accurate and should not be construed as medical advice or diagnosis / treatment recommendations. Please consult a licensed medical provider if you have additional questions. Please call 911 immediately or go to the nearest emergency room if you believe you are experiencing a medical emergency.